Author/Authors :
Wei-Shuo Fang، نويسنده , , Ying Liu، نويسنده , , Hongyan Liu، نويسنده , , Shaofeng Xu، نويسنده , , Liang Wang، نويسنده , , Qi-Cheng Fang، نويسنده ,
Abstract :
Various 2-amido docetaxel analogues were prepared and evaluated for their cytotoxicities. Among them, m-methoxy and m-chlorobenzoylamido analogues were most active but not superior to docetaxel and paclitaxel, and -seco analogues inactive. Change of 2-benzoate to 2-benzamide may not improve their activities to drug-resistant cell lines.
