Synthesis of novel furo, thieno, and benzazetoazepines and evaluation of their cytotoxicity

We report the regio- and stereoselective synthesis of a novel cis-C3N-C4X-C6N series (X=O, S, and C2) from cyclic ketones. The cytotoxic activity of the new compounds was studied in five cell lines; the observed activities were in accordance with the concept of bioisosteric replacement.