Title of article
Focused library approach for identification of new N-acylphenylalanines as VCAM/VLA-4 antagonists
Author/Authors
Li Chen، نويسنده , , Richard Trilles، نويسنده , , Dorota Miklowski، نويسنده , , Tai-Nan Huang، نويسنده , , David Fry، نويسنده , , Robert Campbell، نويسنده , , Karen Rowan، نويسنده , , Virginia Schwinge، نويسنده , , Jefferson W. Tilley، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
1679
To page
1682
Abstract
A structure-based focused library approach was employed in an effort to identify more lipophilic replacements for the N-benzylpyroglutamyl group of the VCAM/VLA-4 antagonist 2. This effort led to the discovery of two new classes of potent antagonists characterized by the N-(α-phenylcyclopentanoyl- and the N-(2,6-dimethylbenzoyl)-derivatives 60 and 64.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792287
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