Title of article :
Pyrrolidine-5,5-trans-lactams as novel mechanism-based inhibitors of human cytomegalovirus protease. Part 3: potency and plasma stability
Author/Authors :
Alan D. Borthwick، نويسنده , , Anne M. Exall، نويسنده , , Terry M. Haley، نويسنده , , Deborah L. Jackson، نويسنده , , Andrew M. Mason، نويسنده , , Gordon G. Weingarten، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2002
Abstract :
Mechanism-based inhibitors of HCMV protease, which are stable to human plasma (≥20 h) and have single-figure potency in the μM range against HCMV protease, have been developed based on the dansylproline α-methyl pyrrolidine-5,5-trans-lactam nucleus.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
