Author/Authors :
Elisa Peroni، نويسنده , , Gabriella Caminati، نويسنده , , Piero Baglioni، نويسنده , , Francesca Nuti، نويسنده , , Mario Chelli، نويسنده , , Anna M. Papini، نويسنده ,
Abstract :
The new fluorescent lipophilic moiety 11-[(7-amino-4-methyl-2-oxo-2H-1-benzopyran-3-acetyl)amino]undecanoic acid (AMCA-ωAud-OH) was introduced by SPPS at the N-terminus of the immunodominant epitope GpMBP(74–85). FRET experiments using the new fluorescent lipopeptide demonstrate that the peptide interacts with much more affinity with the membrane compared to the lipid free analogue.
