Author/Authors :
Raymond G. Lovey، نويسنده , , Anil K. Saksena، نويسنده , , Viyyoor M. Girijavallabhan، نويسنده , , Paul Blundell، نويسنده , , Henry Guzik، نويسنده , , David Loebenberg، نويسنده , , Raulo M. Parmegiani، نويسنده , , Anthony Cacciapuoti، نويسنده ,
Abstract :
The four 2,2,5-regioisomer counterparts of SCH 51048 were synthesized and evaluated. As with the parent series, only the two cis isomers possessed any in vitro activity, and only the activity of the isomer with the R-configuration at the tetrahydrofuran 2-carbon was significant. The activity data suggests that oxygen at only one of the two possible ring positions benzylic to the difluorobenzene participates usefully in active site binding.
