Title of article :
The synthesis and structure–activity relationships of 4-aryl-3-aminoquinolin-2-ones: a new class of calcium-Dependent, large conductance, potassium (maxi-K) channel openers targeted for post-stroke neuroprotection
Author/Authors :
Piyasena Hewawasam*[1]، نويسنده , , Wenhong Fan، نويسنده , , Jay Knipe، نويسنده , , Sandra L. Moon، نويسنده , , Christopher G. Boissard، نويسنده , , Valentin K. Gribkoff، نويسنده , , John E. Starrett Jr.، نويسنده ,
Abstract :
A series of 4-aryl-3-aminoquinoline-2-one derivatives was synthesized and evaluated as activators of the cloned maxi-K channel mSlo (hSlo) expressed in Xenopus laevis oocytes using electrophysiological methods. A brain penetrable activator of maxi-K channels was identified and shown to be significantly active in the MCAO model of stroke.
