Synthesis of C-8 Alkylamino substituted pyrrolo[2,1-c][1,4]benzodiazepines as potential anti-Cancer agents

The design and facile synthesis of C-8 alkylamino substituted pyrrolo[2,1-c][1,4]benzodiazepines is described. These have been prepared by linking the amines at C-8 position with propane spacer to improve solubility in water, and their in vitro cytotoxicity studies have been carried out.