Title of article
Synthesis and anti-influenza virus activity of 4-guanidino-7-substituted Neu5Ac2en derivatives
Author/Authors
Takeshi Honda، نويسنده , , Takeshi Masuda، نويسنده , , Shuku Yoshida، نويسنده , , Masami Arai، نويسنده , , Yoshiyuki Kobayashi، نويسنده , , Makoto Yamashita، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
1921
To page
1924
Abstract
Substitution of 7-OH by small hydrophobic groups on zanamivir resulted in the retaining of low nanomolar inhibitory activities against not only influenza A virus sialidase but also influenza A virus in cell culture. These compounds were prepared by treatment of the corresponding 7-substituted sialic acids derived from 4-modified N-acetyl- -mannosamine (ManNAc) using enzyme-catalyzed aldol condensation.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792343
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