Title of article :
A Convenient Synthesis of Δ7,8-Morphinan-6-one and Its Direct Oxidation to 14-Hydroxy-Δ7,8-morphinan-6-one
Author/Authors :
Daniele Passarella، نويسنده , , Alessandra Consonni، نويسنده , , Alessandra Giardini، نويسنده , , Giordano Lesma، نويسنده , , Alessandra Silvani، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2002
Abstract :
Synthesis of Δ7,8-morphinan-6-one by Grewe cyclization and bromoketalization reaction as crucial steps is described. Introduction of a hydroxyl group at 14-position is demonstrated by direct oxidation with MnO2 in the presence of silica gel.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
