Author/Authors :
Mase Lee، نويسنده , , Malgorzata Dukat، نويسنده , , Liang Liao، نويسنده , , Dwight Flammia، نويسنده , , M. Imad Damaj، نويسنده , , Billy Martin، نويسنده , , Richard A. Glennon، نويسنده ,
Abstract :
A total of 24 aryl-substituted analogues of nicotine (1a) and two related series of nicotinic ligands, aminomethylpyridines 3 and ether analogues 8, were examined to determine if they bind at α4β2 nACh receptors in a common manner. A modest correlation (r=0.785) was found between the affinities of the nicotine analogues and derivatives of 3, but little correlation (r=0.348) was found with analogues 8. However, a modest correlation (r=0.742) exists between the binding of analogues 3 and 8. It seems that 1-series and 8-series compounds bind differently but that the 3-series compounds share some intermediate binding similarity with both.
