Novel cyclourethane-Derived HIV protease inhibitors: A ring-closing olefin metathesis based strategy
Author/Authors :
Arun K. Ghosh، نويسنده , , Lisa M. Swanson، نويسنده , , Chunfeng Liu، نويسنده , , Khaja Azhar Hussain، نويسنده , , Hanna Cho، نويسنده , , D. Eric Walters، نويسنده , , Louis Holland، نويسنده , , Jim Buthod، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2002
Pages :
4
From page :
1993
To page :
1996
Abstract :
A series of novel macrocyclic urethanes incorporating a (R)-hydroxyethylamine isostere was designed and synthesized. Ring size and substituent efffects have been investigated. Cyclourethanes containing 14- to 16-membered rings exhibited low nanomolar inhibitory potencies against HIV-1 protease.
