Title of article
Inhibition of Src kinase activity by 4-anilino-7-thienyl-3-quinolinecarbonitriles
Author/Authors
Diane H. Boschelli، نويسنده , , Daniel Y. Wang، نويسنده , , Fei Ye، نويسنده , , Ayako Yamashita، نويسنده , , Nan Zhang، نويسنده , , Dennis Powell، نويسنده , , Jennifer Weber، نويسنده , , Frank Boschelli، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
2011
To page
2014
Abstract
Based on a screening lead from a yeast-based assay to identify Src family kinase inhibitors, a series of 4-anilino-7-thienyl-3-quinolinecarbonitriles was prepared. When the thiophene ring was substituted with a water-solubilizing group in a 2,5-, 3,5- or 2,4-pattern, potent inhibition of Src kinase activity was observed.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792364
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