Author/Authors :
Diane H. Boschelli، نويسنده , , Daniel Y. Wang، نويسنده , , Fei Ye، نويسنده , , Ayako Yamashita، نويسنده , , Nan Zhang، نويسنده , , Dennis Powell، نويسنده , , Jennifer Weber، نويسنده , , Frank Boschelli، نويسنده ,
Abstract :
Based on a screening lead from a yeast-based assay to identify Src family kinase inhibitors, a series of 4-anilino-7-thienyl-3-quinolinecarbonitriles was prepared. When the thiophene ring was substituted with a water-solubilizing group in a 2,5-, 3,5- or 2,4-pattern, potent inhibition of Src kinase activity was observed.
