Author/Authors :
Ramin Faghih، نويسنده , , Wesley Dwight، نويسنده , , Robert Gentles، نويسنده , , Kathleen Phelan، نويسنده , , Timothy A. Esbenshade، نويسنده , , Lynne Ireland، نويسنده , , Thomas R. Miller، نويسنده , , Chae-Hee Kang، نويسنده , , Gerard B. Fox، نويسنده , , Sujatha M. Gopalakrishnan، نويسنده , , Arthur A. Hancock، نويسنده , , Youssef L. Bennani، نويسنده ,
Abstract :
SAR studies for novel non-imidazole containing H3 receptor antagonists with high potency and selectivity for rat H3 receptors are described. A high throughput screening lead, A-923, was further elaborated in a systematic manner to clarify a pharmacophore for this class of aryloxyalkyl piperazine based compounds.
