Title of article
Apoptosis-Inducing activity of synthetic intermediates of Halichlorine
Author/Authors
Midori Itoh، نويسنده , , Jun Kuwahara، نويسنده , , Kohji Itoh، نويسنده , , Yu-ichi Fukuda، نويسنده , , Mikiko Kohya، نويسنده , , Mitsuru Shindo، نويسنده , , Kozo Shishido، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
2069
To page
2072
Abstract
Synthetic intermediates of alkaloid halichlorine with the azaspiro core structure have been found to induce apoptosis of cultured human cells including an acute monocytic leukemia cell line (THP-1) at micromolar concentrations. The novel biological activity of the intermediates was suggested to depend on the skeletal structure and silyloxymethyl functionality on the five-membered ring.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792377
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