• Title of article

    Pyrrolylquinoxalinediones carrying a piperazine residue represent highly potent and selective ligands to the homomeric kainate receptor GluR5

  • Author/Authors

    W. Lubisch، نويسنده , , B. Behl، نويسنده , , C. Henn، نويسنده , , H. P. Hofmann، نويسنده , , J. Reeb، نويسنده , , F. Regner، نويسنده , , John M. Vierling، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2002
  • Pages
    4
  • From page
    2113
  • To page
    2116
  • Abstract
    Pyrrolylquinoxalinediones carrying aminoalkyl residues were evaluated for affinity to the recombinant, homomeric kainate receptors GluR5, GluR6 and GluR7. Most derivatives preferred binding to GluR5. In particular, the piperazine 6e represents a highly potent and selective antagonist to GluR5.
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2002
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    792387