Author/Authors :
Jun Yuan، نويسنده , , Michael Gulianello، نويسنده , , Stéphane De Lombaert، نويسنده , , Robbin Brodbeck، نويسنده , , Andrzej Kieltyka، نويسنده , , Kevin J. Hodgetts، نويسنده ,
Abstract :
The synthesis of a series of 3-aryl pyrazolo[4,3-d]pyrimidines as potential corticotropin-releasing factor (CRF-1) antagonists is described. The effects of substitution on the aromatic ring, the amino group and the pyrazolo ring on CRF-1 receptor binding were investigated.
