Antifungal activity of bifunctional sphingolipids. intramolecular synergism within long-chain α,ω-bis-aminoalcohols

The in vitro antifungal activity of a series of α,ω-bifunctionalized aminoalcohols against Candida glabrata was measured. The dimeric bi-functionalized lipids exhibited activity about 10-fold higher higher than -sphingosine, which is a larger factor than expected from the simple additive effects of vicinal aminoalcohols groups.