Author/Authors :
Wenqian Yang، نويسنده , , Shouhai Gao، نويسنده , , Xingming Gao، نويسنده , , Vishnu Vardhan Reddy Karnati، نويسنده , , Weijuan Ni، نويسنده , , Binghe Wang، نويسنده , , W. Borden Hooks، نويسنده , , John Carson، نويسنده , , Brent Weston، نويسنده ,
Abstract :
A series of fluorescent diboronic acids was synthesized in nine steps as potential sensors for sialyl Lewis X (sLex). The fluorescent binding studies of these sensors with sLex were carried out in a mixed aqueous solution. Compound 7e was found to show the strongest fluorescence enhancement upon binding with sLex. Using cell cultures, 7e was shown to label sLex-expressing HEPG2 cells at 1 μM, while non-sLex-expressing cells were not labeled.
