Discovery of potent, selective human granzyme B inhibitors that inhibit CTL mediated apoptosis
Author/Authors :
Christopher A. Willoughby، نويسنده , , Herbert G. Bull، نويسنده , , Margarita Garcia-Calvo، نويسنده , , Joanne Jiang، نويسنده , , Kevin T. Chapman، نويسنده , , Nancy A. Thornberry، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2002
Pages :
4
From page :
2197
To page :
2200
Abstract :
A novel class of small molecule human granzyme B inhibitors is reported. Compound 20 has a Ki of 7 nM against human granzyme B and blocks CTL mediated apoptosis with an IC50 of 3 micromolar.
