Title of article
Identification of a novel partial inhibitor of dopamine transporter among 4-substituted 2-phenylquinazolines
Author/Authors
Subramaniam Ananthan، نويسنده , , Surendra K. Saini، نويسنده , , Rashmi Khare، نويسنده , , Sarah D. Clayton، نويسنده , , Christina M. Dersch، نويسنده , , Richard B. Rothman، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
2225
To page
2228
Abstract
In an attempt to identify novel ligands for the dopamine transporter, a series of 4-substituted-2-phenylquinazolines were synthesized and evaluated. Among the compounds studied, 4-[(diphenylmethyl)amino]-2-phenylquinazoline (4g) was identified as a novel partial inhibitor of [125I]RTI-55 binding to the dopamine transporter and a partial inhibitor of [3H]dopamine uptake.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792414
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