Identification of a novel partial inhibitor of dopamine transporter among 4-substituted 2-phenylquinazolines

In an attempt to identify novel ligands for the dopamine transporter, a series of 4-substituted-2-phenylquinazolines were synthesized and evaluated. Among the compounds studied, 4-[(diphenylmethyl)amino]-2-phenylquinazoline (4g) was identified as a novel partial inhibitor of [125I]RTI-55 binding to the dopamine transporter and a partial inhibitor of [3H]dopamine uptake.