Title of article
Design, synthesis and biological activity of carbohydrate-Containing peptidomimetics as new ligands for the human tachykinin NK-2 receptor
Author/Authors
Giuseppe Capozzi، نويسنده , , Sabrina Giannini، نويسنده , , Stefano Menichetti، نويسنده , , Cristina Nativi، نويسنده , , Alessandro Giolitti، نويسنده , , Riccardo Patacchini، نويسنده , , Enzo Perrotta، نويسنده , , Maria Altamura، نويسنده , , Carlo Alberto Maggi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
2263
To page
2266
Abstract
Enantiopure cycloadducts between glycals and alkyl or aryl heterodienes were selected as small, rigid, nonpeptide molecules able to superimpose to the structure of the cyclopeptide tachykinin NK-2 antagonist 1. The presence of three aromatic groups in the pyranose ring resulted essential for NK-2 affinity, while an increase in activity was shown by the corresponding sulfoxides.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792420
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