Title of article
Synthesis of [(2S,3S,4R)-3,4-Dihydroxypyrrolidin-2-yl]-5-methylfuran-4-carboxylic Acid Derivatives: New Leads as Selective β-Galactosidase Inhibitors
Author/Authors
Antonio J. Moreno-Vargas، نويسنده , , Raynald Demange، نويسنده , , José Fuentes، نويسنده , , Inmaculada Robina، نويسنده , , Jean-Claude Hausmann and Pierre Vogel، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
5
From page
2335
To page
2339
Abstract
The preparation of [(2S,3S,4R)-3,4-dihydroxypyrrolidin-2-yl]furan derivatives in a stereoselective route starting from -glucose and ethyl acetoacetate is presented. Ethyl ester (6), N,N-diethylamide (7) and N-isopropylamide (8) have been tested towards 25 glycosidases. Ester (6) is a selective inhibitor of β-galactosidases. The new compounds represent a new type of imino-C-nucleoside analogues.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792439
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