Author/Authors :
Gregory A. Reichard، نويسنده , , Cheryl A. Grice، نويسنده , , Neng-Yang Shih، نويسنده , , James Spitler، نويسنده , , Sapna Majmundar، نويسنده , , Steven D. Wang، نويسنده , , Sunil Paliwal، نويسنده , , John C. Anthes، نويسنده , , John J. Piwinski، نويسنده ,
Abstract :
By employing a stereosimplification approach, a thorough SAR exploration of the piperidine region of Sch 206272 was possible through a practical and efficient synthesis of substituted cyclic ureas. This SAR study led to the identification of a benzimidazolinone series of compounds which display single digit nanomolar NK1/NK2 affinity and near micromolar binding for the NK3 receptor.
