Title of article
Synthesis and Biological Evaluation of Novel -2′-Azido-2′,3′-dideoxyarabinofuranosyl-4′-thiopyrimidines and purines
Author/Authors
Hea Ok Kim، نويسنده , , Yong-Hee Park، نويسنده , , Hyung Ryong Moon، نويسنده , , Lak Shin Jeong، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
2403
To page
2406
Abstract
Novel -2′-azido-2′,3′-dideoxyarabinofuranosyl-4′-thiopyrimidines and purines have been synthesized, starting from -xylose via azidation at the 2′-position as a key step. Most of the final nucleosides exhibited toxicity-dependent anti-HIV-1 activity, among which -α-adenine analogue 3h was found to be the most cytotoxic.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792459
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