Title of article
N-Cycloalkanoyl- -Phenylalanine Derivatives as VCAM/VLA-4 Antagonists
Author/Authors
Achyutharao Sidduri، نويسنده , , Jefferson W. Tilley، نويسنده , , Kenneth Hull، نويسنده , , Jian Ping Lou، نويسنده , , Gerry Kaplan، نويسنده , , Allen Sheffron، نويسنده , , Li Chen، نويسنده , , Robert Campbell، نويسنده , , Robert Guthrie، نويسنده , , Tai-Nan Huang، نويسنده , , Nicholas Huby، نويسنده , , Karen Rowan، نويسنده , , Virginia Schwinge، نويسنده , , Louis M. Renzetti، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
2475
To page
2478
Abstract
A systematic structure–activity relationship investigation of the lead compound 1 resulted the identification of several N-[(substituted alkyl)cycloalkanoyl]-4-[((2,6-dichlorophenyl)carbonyl)amino]- -phenylalanine derivatives as potent VCAM/VLA-4 antagonists. The data are consistent with a model of these compounds in which these alkanoylphenylalanines reside in a compact gauche (−) bioactive conformation.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792477
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