Author/Authors :
Gillian M. Nicholas، نويسنده , , Lisa L. Eckman، نويسنده , , Satyajit Ray، نويسنده , , Robert O. Hughes، نويسنده , , Jeffrey A. Pfefferkorn، نويسنده , , Sofia Barluenga، نويسنده , , K. C. Nicolaou، نويسنده , , Carole A. Bewley، نويسنده ,
Abstract :
A series of bromotyrosine-derived compounds, including marine natural products and members of a psammaplin A-inspired combinatorial synthetic library, were screened for their ability to inhibit the Mycobacterium tuberculosis detoxification enzyme mycothiol-S-conjugate amidase (MCA). Correlations between the structures and their respective IC50 values (which range from 3 μM to 2.7 mM) should prove valuable when optimizing more potent inhibitors of MCA.
