Author/Authors :
Roland W. Bürli، نويسنده , , Yigong Ge، نويسنده , , Sarah White، نويسنده , , Eldon E. Baird، نويسنده , , Sofia M. Touami، نويسنده , , Matthew Taylor، نويسنده , , Jacob A. Kaizerman، نويسنده , , Heinz E. Moser، نويسنده ,
Abstract :
An efficient synthesis of DNA binding molecules consisting of four heterocyclic carboxamide units and various substituents at both termini is described. The minor-groove binding ligands showed excellent activity against a broad range of Gram-positive bacteria; no cross-resistance to known antibacterial drugs was observed.
