Author/Authors :
A. Ryckebusch، نويسنده , , R. Déprez-Poulain، نويسنده , , M. -A. Debreu-Fontaine، نويسنده , , R. Vandaele، نويسنده , , E. Mouray، نويسنده , , P. Grellier، نويسنده , , C. Sergheraert، نويسنده ,
Abstract :
Solution-phase synthesis and evaluation of a library of 31 sulfonamides as inhibitors of a chloroquine-resistant strain of Plasmodium falciparum are described. The most potent compound displayed an activity 100-fold better than chloroquine. Experiments using a fluorescent sulfonamide derivative suggest that their site of action inside the parasite is different to that of chloroquine.
