Author/Authors :
Young-Sik Jung، نويسنده , , Tae-Souk Kang، نويسنده , , Joong-Ho Yoon، نويسنده , , Bo-Young Joe، نويسنده , , Hee-Jong Lim، نويسنده , , Churl-Min Seong، نويسنده , , Woo-Kyu Park، نويسنده , , Jae Yang Kong، نويسنده , , Jungsook Cho، نويسنده , , No-Sang Park، نويسنده ,
Abstract :
4-Hydroxyphenylacetic acid amides and 4-hydroxycinnamamides were synthesized and their antioxidant and neuroprotective activities were evaluated. Among the prepared compounds, 6f, 6g, 8b, and 9 exhibited potent inhibition of lipid peroxidation in rat brain homogenates, and marked DPPH radical scavenging activities. Furthermore, 6f, 6g, and 9 exhibited neuroprotective action against the oxidative damage induced by the exposure of primary cultured rat cortical cells to H2O2, xanthine/xanthine oxidase, or Fe2+/ascorbic acid. Based on these results, we found that 6f was the most potent antioxidant among the compounds tested.
