Author/Authors :
Dan Berger، نويسنده , , Minu Dutia، نويسنده , , Dennis Powell، نويسنده , , Biqi Wu، نويسنده , , Allan Wissner، نويسنده , , Frenel DeMorin، نويسنده , , Jennifer Weber، نويسنده , , Frank Boschelli، نويسنده ,
Abstract :
A series of 8-anilinoimidazo[4,5-g]quinoline-7-carbonitriles was synthesized and evaluated as Src kinase inhibitors. Several aniline substituents were surveyed, as well as water-solubilizing groups at the C-2 and N-3 positions. Potent Src inhibitors were identified, with N-3 providing the best position for an additional water-solubilizing group.
