Author/Authors :
Nobutoshi Murakami، نويسنده , , Ying Ye، نويسنده , , Motoyuki Kawanishi، نويسنده , , Shunji Aoki، نويسنده , , Nobuaki Kudo، نويسنده , , Minoru Yoshida، نويسنده , , Emi E. Nakayama، نويسنده , , Tatsuo Shioda، نويسنده , , Motomasa Kobayashi، نويسنده ,
Abstract :
Bioassay-guided separation by use of the fission yeast expressing NES of Rev, a HIV-1 viral regulatory protein, resulted in isolation of valtrate (1) as a new Rev-transport inhibitor from the nucleus to cytoplasm from Valerianae Radix. Valtrate (1) also inhibited the p-24 production of HIV-1 virus without showing any cytotoxicity against the host MT-4 cells.
