Author/Authors :
James N. Reynolds، نويسنده , , Brian M. Bennett، نويسنده , , Roland J. Boegman، نويسنده , , Khem Jhamandas، نويسنده , , Jodan D. Ratz، نويسنده , , Sergei I. Zavorin، نويسنده , , Dan Scutaru، نويسنده , , Adina Dumitrascu، نويسنده , , Gregory R. J. Thatcher، نويسنده ,
Abstract :
Nitrates exhibit a selectivity of action in different tissue types not fully recognized: in particular, the neuromodulatory and cardiovascular properties can be dissociated. A novel nitrate showed relatively weak systemic effects, but in the middle cerebral artery occlusion rat model of focal ischemia, reduced the cerebral infarct by 60–70% when administered 4 h after the onset of ischemia.
