Author/Authors :
Michael L. Curtin، نويسنده , , Robert B. Garland، نويسنده , , H. Robin Heyman، نويسنده , , Robin R. Frey، نويسنده , , Michael R. Michaelides، نويسنده , , Junling Li، نويسنده , , Lori J. Pease، نويسنده , , Keith B. Glaser، نويسنده , , Patrick A. Marcotte، نويسنده , , Steven K. Davidsen، نويسنده ,
Abstract :
A series of succinimide hydroxamic acids was prepared and evaluated in vitro for HDAC inhibition and tumor cell antiproliferation. While the original macrocyclic analogue 6 was quite potent in both assays, several appropriately substituted non-macrocyclic succinimides, such as 23, were equipotent.
