Author/Authors :
Edwin J. Iwanowicz، نويسنده , , Scott H. Watterson، نويسنده , , Chunjian Liu، نويسنده , , Henry H. Gu، نويسنده , , Toomas Mitt، نويسنده , , Katerina Leftheris، نويسنده , , Joel C. Barrish، نويسنده , , Catherine A. Fleener، نويسنده , , Katherine Rouleau، نويسنده , , N. Z. Sherbina، نويسنده , , Diane L. Hollenbaugh، نويسنده ,
Abstract :
A series of novel guanidine-based small molecule inhibitors of inosine monophosphate dehydrogenase (IMPDH) was explored. IMPDH catalyzes the rate determining step in guanine nucleotide biosynthesis and is a target for anticancer, immunosuppressive and antiviral therapy. The synthesis and the structure–activity relationships (SARs), derived from in vitro studies, for this new series of inhibitors is given.
