Author/Authors :
Venkata P. Palle، نويسنده , , Elfatih O. Elzein، نويسنده , , Scott A. Gothe، نويسنده , , Zhihe Li، نويسنده , , Zhenhai Gao، نويسنده , , Stephanie Meyer، نويسنده , , Brent Blackburn، نويسنده , , Jeff A. Zablocki، نويسنده ,
Abstract :
The structure–affinity relationships of two novel 2-substituted adenosine series containing a substituted pyrazole attached at the N-1 or C-4 position for the adenosine (ADO) A2A receptor are described. Compounds in the 2-(N-1-pyrazolyl) adenosine series IV provided the highest affinity for the ADO A2A receptor as compared to the 2-(C-4-pyrazolyl) series V. The main structural differences between the two series point to the N-1 nitrogen of series IV imparting more favorable binding interactions with the receptor than those of series V.
