Title of article
Successful bridging from a peptide to a non peptide antagonist at the human tachykinin NK-2 receptor
Author/Authors
Maria Altamura، نويسنده , , Franca Canfarini، نويسنده , , Rose-Marie Catalioto، نويسنده , , Antonio Guidi، نويسنده , , Franco Pasqui، نويسنده , , Anna R. Renzetti، نويسنده , , Antonio Triolo، نويسنده , , Carlo A. Maggi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
2945
To page
2948
Abstract
Non peptide products have been found to show nanomolar binding and functional affinities at the human tachykinin NK-2 receptor. The new antagonists do not possess stereogenic centers and their thermal behaviour in solution is featured by a peculiar set of conformational stereoisomers. A macroscopic viewpoint is preferentially adopted to rationalize the obtained results.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792575
Link To Document