Author/Authors :
Dan Berger، نويسنده , , Minu Dutia، نويسنده , , Dennis Powell، نويسنده , , Allan Wissner، نويسنده , , Frenel DeMorin، نويسنده , , Yuri Raifeld، نويسنده , , Jennifer Weber، نويسنده , , Frank Boschelli، نويسنده ,
Abstract :
A series of substituted 4-anilino-7-phenyl-3-quinolinecarbonitriles has been prepared as Src kinase inhibitors. Optimal activity is observed with compounds that have basic amines attached via the para position of the 7-phenyl ring, and a hydrogen atom at the C-6 position. The best compounds are low nanomolar inhibitors of Src kinase, and have potent activity against Src-transformed fibroblast cells.
