Title of article
Synthesis and evaluation of potent pyrrolidine H3 antagonists
Author/Authors
Anil Vasudevan، نويسنده , , Scott E. Conner، نويسنده , , Robert G. Gentles، نويسنده , , Ramin Faghih، نويسنده , , Huaqing Liu، نويسنده , , Wesley Dwight، نويسنده , , Lynne Ireland، نويسنده , , Chae-Hee Kang، نويسنده , , Timothy A. Esbenshade، نويسنده , , Youssef L. Bennani، نويسنده , , Arthur A. Hancock، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
3055
To page
3058
Abstract
The synthesis and biological evaluation of novel antagonists of the rat H3 receptor are described. These compounds differ from prototypical H3 antagonists in that they do not contain an imidazole moiety, but rather a substituted aminopyrrolidine moiety. A systematic modification of the substituents on the aminopyrrolidine ring was performed using pre-formatted precursor sets, where applicable, to afford several compounds with high affinity and selectivity for the H3 receptor.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792598
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