Author/Authors :
Anil Vasudevan، نويسنده , , Scott E. Conner، نويسنده , , Robert G. Gentles، نويسنده , , Ramin Faghih، نويسنده , , Huaqing Liu، نويسنده , , Wesley Dwight، نويسنده , , Lynne Ireland، نويسنده , , Chae-Hee Kang، نويسنده , , Timothy A. Esbenshade، نويسنده , , Youssef L. Bennani، نويسنده , , Arthur A. Hancock، نويسنده ,
Abstract :
The synthesis and biological evaluation of novel antagonists of the rat H3 receptor are described. These compounds differ from prototypical H3 antagonists in that they do not contain an imidazole moiety, but rather a substituted aminopyrrolidine moiety. A systematic modification of the substituents on the aminopyrrolidine ring was performed using pre-formatted precursor sets, where applicable, to afford several compounds with high affinity and selectivity for the H3 receptor.
