Novel nucleotide phosphonate analogues with potent antitumor activity
Author/Authors :
Monica Bubenik، نويسنده , , Rabindra Rej، نويسنده , , Nghe Nguyen-Ba، نويسنده , , Giorgio Attardo، نويسنده , , France Ouellet، نويسنده , , Laval Chan، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2002
Pages :
4
From page :
3063
To page :
3066
Abstract :
We have identified several nucleotide phosphonates demonstrating in vitro antiproliferative activity in several human cancer cell lines with IC50 values in the μM range. The synthesis as well as structure–activity relationship are described.
