Title of article
Indoline and piperazine containing derivatives as a novel class of mixed D2/D4 receptor antagonists. Part 1: Identification and structure–activity relationships
Author/Authors
He Zhao، نويسنده , , Andrew Thurkauf، نويسنده , , Xiaoshu He، نويسنده , , Kevin Hodgetts، نويسنده , , Xiaoyan Zhang، نويسنده , , Stanislaw Rachwal، نويسنده , , Renata X. Kover، نويسنده , , Alan Hutchison، نويسنده , , John Peterson، نويسنده , , Andrzej Kieltyka، نويسنده , , Robbin Brodbeck، نويسنده , , Renee Primus، نويسنده , , Jan W. F. Wasley، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
5
From page
3105
To page
3109
Abstract
Optimization of the lead compound 2-[-4-(4-chloro-benzyl)-piperazin-1-yl]-1-(2,3-dihydro-indol-1-yl)-ethanone 1 by systematic structure–activity relation (SAR) studies lead to two potent compounds 2-[-4-(4-chloro-benzyl)-piperazin-1-yl]-1-(2-methy-2,3-dihydro-indol-1-yl)-ethanone 2n and 2-[-4-(4-chloro-benzyl)-piperazin-1-yl]-1-(2-methy-2,3-dihydro-indol-1-yl)-ethanone 7b. Their related synthesis was also reported.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792610
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