Author/Authors :
Caroline Roy، نويسنده , , Ticheao Li، نويسنده , , Pavel Krasik، نويسنده , , Marie-Josée Gilbert، نويسنده , , Christine Pelletier، نويسنده , , Diane Gagnon، نويسنده , , Ed Robert، نويسنده , , Julie Ducharme، نويسنده , , Richard Storer، نويسنده , , Jean-François Lavallée، نويسنده ,
Abstract :
Several novel racemic aminotetralin derivatives have been prepared using a stereoselective aziridine ring opening reactions and were evaluated for their μ-opioid receptor binding affinity. Selectivity index towards other opioid receptors and antinociceptive activity in mice have been evaluated for the most potent derivatives.
