Author/Authors :
Murray J. Brown، نويسنده , , Paul S. Carter، نويسنده , , Ashley E. Fenwick، نويسنده , , Andrew P. Fosberry، نويسنده , , Dieter W. Hamprecht، نويسنده , , Martin J. Hibbs، نويسنده , , Richard L. Jarvest، نويسنده , , Lucy Mensah، نويسنده , , Peter H. Milner، نويسنده , , Peter J. OʹHanlon، نويسنده , , Andrew J. Pope، نويسنده , , Christine M. Richardson، نويسنده , , Andrew-West، نويسنده , , David R. Witty، نويسنده ,
Abstract :
The antimicrobial natural product chuangxinmycin has been found to be a potent and selective inhibitor of bacterial tryptophanyl tRNA synthetase (WRS). A number of analogues have been synthesised. The interaction with WRS appears to be highly constrained, as only sterically smaller analogues afforded significant inhibition. The only analogue to show inhibition comparable to chuangxinmycin also had antibacterial activity. WRS inhibition may contribute to the antibacterial action of chuangxinmycin.
