Title of article :
P1 Phenethyl peptide boronic acid inhibitors of HCV NS3 protease
Author/Authors :
E. Scott Priestley، نويسنده , , Indawati De Lucca، نويسنده , , Bahman Ghavimi، نويسنده , , Susan Erickson-Viitanen، نويسنده , , Carl P. Decicco، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2002
Abstract :
A series of peptide boronic acids containing extended, hydrophobic P1 residues was prepared to probe the shallow, hydrophobic S1 region of HCV NS3 protease. The p-trifluoromethylphenethyl P1 substituent was identified as optimal with respect to inhibitor potency for NS3 and selectivity against elastase and chymotrypsin.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
