Author/Authors :
Vinod R. Hegde، نويسنده , , T. -M. Chan، نويسنده , , Haiyan Pu، نويسنده , , Vincent P. Gullo، نويسنده , , Mahesh G. Patel، نويسنده , , Pradip Das، نويسنده , , Nicole Wagner، نويسنده , , P. S. Parameswaran، نويسنده , , C. G. Naik، نويسنده ,
Abstract :
The aqueous methanolic extract of a sea cucumber was found to contain two triterpene glycosides 1 and 2. The structures of 1 and 2 were established based on high-resolution NMR studies. Compounds 1 and 2 exhibited inhibitory activity (Ki) of 30 and 5 μM, respectively, in a chemokine receptor subtype 5 (CCR5) assay. Both compounds did not show any significant inhibition in a CXCR2 assay at 50 μM, suggesting their selectivity for the CCR5 receptor.
