Author/Authors :
Chandra Shah، نويسنده , , Laura McAtee، نويسنده , , J. Guy Breitenbucher، نويسنده , , Dale Rudolph، نويسنده , , Xiaobing Li، نويسنده , , Timothy W. Lovenberg، نويسنده , , Curt Mazur، نويسنده , , Sandy J. Wilson، نويسنده , , Nicholas I. Carruthers، نويسنده ,
Abstract :
High throughput screening, using the recombinant human H3 receptor, was used to identify novel histamine H3 receptor antagonists. Evaluation of the lead compounds ultimately afforded potent, selective, orally bioavailable compounds (e.g., 38) with favorable blood–brain barrier penetration.
