Title of article :
6-Acylamino-penam derivatives: synthesis and inhibition of cathepsins B, L, K, and S
Author/Authors :
Nian E. Zhou، نويسنده , , Jadwiga Kaleta، نويسنده , , Enrico Purisima، نويسنده , , Robert Menard، نويسنده , , Ronald G. Micetich، نويسنده , , Rajeshwar Singh، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2002
Abstract :
The synthesis of a new series of 6-acylamino penam derivatives and their inhibition of cysteine proteases cathepsins B, L, K, and S is described. The 6-acylamino-penam sulfone compounds showed excellent cathepsin L, K, and S inhibition activity with IC50 values in the nanomolar and subnanomolar range.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
