Title of article
Isolation and antimalarial activity of peroxydisulfate oxidation products of primaquine
Author/Authors
Virendra K. Dua، نويسنده , , Sukesh N. Sinha، نويسنده , , Sukla Biswas، نويسنده , , N. Valecha، نويسنده , , S. K. Puri، نويسنده , , V. P. Sharma، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
3
From page
3587
To page
3589
Abstract
Five compounds formed by peroxydisulfate oxidation of primaquine were isolated using chromatographic methods and evaluated for antimalarial activity in vitro. One compound 6-methoxy-5,8 bis(4′-amino-1′-methylbutylamino)quinoline [P1] was found to have good gametocytocidal activity against Plasmodium yoelli infected mice at 10 mg kg−1 dose in vivo.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792720
Link To Document