Isolation and antimalarial activity of peroxydisulfate oxidation products of primaquine

Five compounds formed by peroxydisulfate oxidation of primaquine were isolated using chromatographic methods and evaluated for antimalarial activity in vitro. One compound 6-methoxy-5,8 bis(4′-amino-1′-methylbutylamino)quinoline [P1] was found to have good gametocytocidal activity against Plasmodium yoelli infected mice at 10 mg kg−1 dose in vivo.