Author/Authors :
Ken-ichi Kawasaki، نويسنده , , Miyako Masubuchi، نويسنده , , Kenji Morikami، نويسنده , , Satoshi Sogabe، نويسنده , , Tsunehisa Aoyama، نويسنده , , Hirosato Ebiike، نويسنده , , Satoshi Niizuma، نويسنده , , Michiko Hayase، نويسنده , , Toshihiko Fujii، نويسنده , , Kiyoaki Sakata، نويسنده , , Hidetoshi Shindoh، نويسنده , , Yasuhiko Shiratori، نويسنده , , Yuko Aoki، نويسنده , , Tatsuo Ohtsuka، نويسنده , , Nobuo Shimma، نويسنده ,
Abstract :
A new series of acid-stable antifungal agents having strong inhibitory activity against Candida albicans N-myristoyltransferase (CaNmt) has been developed starting from acid-unstable benzofuranylmethyl aryl ether 2. The inhibitor design is based on X-ray crystallographic analysis of a CaNmt complex with aryl ether 3. Among the new inhibitors, pyridine derivative 8b and benzimidazole derivative 8k showed clear antifungal activity in a murine systemic candidiasis model.
