Title of article
Structure–activity and crystallographic analysis of benzophenone derivatives—the potential anticancer agents
Author/Authors
Hsing-Pang Hsieh، نويسنده , , Jing-Ping Liou، نويسنده , , Ying-Ting Lin، نويسنده , , Neeraj Mahindroo، نويسنده , , Jang-Yang Chang، نويسنده , , Yung-Ning Yang، نويسنده , , Shuenn-Shing Chern، نويسنده , , Uan-Kang Tan، نويسنده , , Chun-Wei Chang، نويسنده , , Tung-Wei Chen، نويسنده , , Chi-Hung Lin، نويسنده , , Ying-Ying Chang، نويسنده , , Chiung-Chiu Wang، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
5
From page
101
To page
105
Abstract
Compounds 1–5, structurally related to combretastatin A-4 showed excellent cytotoxic activities against a panel of human cancer cell lines including multi-drug resistant cell lines. The X-ray three-dimensional structural analysis shows that proton donor in B ring may be required for cytotoxic activity, with intermolecular hydrogen bonding playing an important role.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792869
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