Author/Authors :
Hsing-Pang Hsieh، نويسنده , , Jing-Ping Liou، نويسنده , , Ying-Ting Lin، نويسنده , , Neeraj Mahindroo، نويسنده , , Jang-Yang Chang، نويسنده , , Yung-Ning Yang، نويسنده , , Shuenn-Shing Chern، نويسنده , , Uan-Kang Tan، نويسنده , , Chun-Wei Chang، نويسنده , , Tung-Wei Chen، نويسنده , , Chi-Hung Lin، نويسنده , , Ying-Ying Chang، نويسنده , , Chiung-Chiu Wang، نويسنده ,
Abstract :
Compounds 1–5, structurally related to combretastatin A-4 showed excellent cytotoxic activities against a panel of human cancer cell lines including multi-drug resistant cell lines. The X-ray three-dimensional structural analysis shows that proton donor in B ring may be required for cytotoxic activity, with intermolecular hydrogen bonding playing an important role.
